Dr. Dorothea Portius

Focus areas: AI in personalized nutrition • Sensor technologies • Women’s health • Preventive medicine • Non-invasive diagnostics • personalized nutriton and longevity- Lead applied research integrating sensor technologies and AI to develop personalized nutrition solutions across medical and preventive settings - Design and implement non-invasive, sensor-based research frameworks to assess nutrition-related physiological and biochemical parameters - Develop AI-driven personalized nutrition concepts, with a current focus on menopause and women’s health - develp a digital nutrition advisory tool, translating complex sensor and health data into actionable recommendations - Build and coordinate industry, academic, and clinical collaborations to advance translational personalized nutrition - Expand personalized nutrition applications into oncology support, medical prevention, and non-invasive diagnostics - Acquire third-party funding, publish peer-reviewed research, and actively contribute to teaching and supervision within the Personalized Nutrition program Focus areas: AI in personalized nutrition • Sensor technologies • Women’s health • Preventive medicine • Non-invasive diagnostics • personalized nutriton and longevity

Preventive digital health • Eating behavior & metabolism • Personalized nutrition • Science-based health tools • Startup & grant funding (EXIST)

https://www.f-50.app/- Co-founded f-50 with the vision of creating a science-based, preventive digital health tool supporting individuals of all genders with problematic eating behaviors and metabolic challenges - Shaped the scientific foundation and health strategy of the app, contributing expertise in nutrition science, metabolism, and evidence-informed behavior change - Co-developed the nutritional and scientific program, translating current research into accessible, everyday guidance (a “digital health buddy for the pocket”) - Provided scientific leadership across product and content development, ensuring credibility, relevance, and alignment with preventive public health principles - Initiated and actively supported the successful EXIST funding application, contributing to scientific rationale, program logic, and strategic positioning - Acted as a scientific sparring partner for the founding team, supporting decision-making at the intersection of science, technology, and user needs - The project was discontinued due to the lack of continuous follow-up funding, despite a strong preventive concept and validated scientific framework Preventive digital health • Eating behavior & metabolism • Personalized nutrition • Science-based health tools • Startup & grant funding (EXIST) https://www.f-50.app/

Bariatric nutrition • Clinical supplementation • Evidence-based product innovation • Medical advisory boards • Scientific communication- Serve on the Medical Advisory Board, providing strategic scientific and medical input on bariatric nutrition and targeted supplementation - Contribute expert guidance during board meetings on current evidence, emerging research, and clinically relevant developments in bariatrics - Advise on product improvement and innovation, including new formulations, ingredient selection, and evidence-based updates to existing products - Identify and discuss promising research directions and critical evidence gaps, informing FitForMe’s research and product roadmap - Support the translation of scientific insights into product development concepts, strengthening clinical relevance and product differentiation - Represent FitForMe at scientific and medical congresses, delivering scientific presentations on bariatric nutrition and supplementation - Contribute to professional and public education, reviewing and authoring scientific and educational content (e.g. newsletters, expert materials) Bariatric nutrition • Clinical supplementation • Evidence-based product innovation • Medical advisory boards • Scientific communication

Health services research • Health economic evaluation • Innovation Fund (G-BA) • Public health • Mixed-methods research • Project & team leadership- Lead and manage complex evaluation and health research projects, with a focus on public health, and innovative forms of healthcare delivery - Provide strategic scientific consulting to clients and stakeholders, shaping evaluation approaches for large-scale health and innovation projects - Design and oversee health economic evaluations, including projects funded through the Innovation Fund (Innovationsfonds, G-BA) - Develop robust evaluation concepts using quantitative, qualitative, and mixed-method designs, tailored to project goals and regulatory requirements - Contribute to and coordinate the development of public health and healthcare innovation funding applications, including the conceptualization, writing, and management of Innovationsfonds and other proposals - Acquire research funding and support successful project approvals through strong methodological and strategic positioning - Lead interdisciplinary scientific teams, ensuring methodological quality, timely delivery, and high-impact outputs - Conduct and supervise qualitative and quantitative research, translating findings into actionable insights for healthcare decision-making Health services research • Health economic evaluation • Innovation Fund (G-BA) • Public health • Mixed-methods research • Project & team leadership

Nutritional therapy • Clinical nutrition • Applied research • Industry & clinical collaboration • Academic program development • Scientific leadership- Develop and expand the Nutritional Science study program (nutritional therapy and counseling), shaping academic content, structure, and strategic direction - Represent the study program independently in academic, professional, and external contexts, strengthening its visibility and positioning - Oversee and supervise bachelor’s and master’s theses, ensuring scientific rigor and practical relevance - Initiate and lead applied research and student projects in collaboration with industry partners (e.g., supplement and prebiotic industry) and clinical partners (e.g., bariatric surgery, pain medicine, oncology) - Build and manage interdisciplinary teaching and research teams, including lecturers and research staff - Design, establish, and lead research projects, including the development and writing of funding applications at the national and international level - Contribute to interdisciplinary research proposals, collaborating across disciplines and institutions - Actively participate in academic governance and scientific committees, contributing to the conceptual development of the department - Present research and professional expertise at national and international congresses, and participate in specialist conferences and symposia Nutritional therapy • Clinical nutrition • Applied research • Industry & clinical collaboration • Academic program development • Scientific leadership

Translational research • Preclinical models • RNA biology • CRISPR/Cas systems • Drug discovery • Cardiovascular research • biomolecualr research- Lead translational and preclinical research projects focused on cardiovascular disease, with an emphasis on atrial fibrillation and associated heart failure - Identify and validate novel therapeutic targets using RNA-based approaches in in vivo (mouse models) and in vitro (cell culture) systems - Design and execute complex experimental strategies, including project planning, timelines, and end-to-end scientific execution - Develop and establish advanced biomolecular methods, including the application of CRISPR/Cas-based systems for functional target analysis - Design and perform high-throughput screening approaches to support early-stage drug discovery and target prioritization - Supervise and mentor students, guiding experimental design, data interpretation, and scientific development - Contribute to scientific leadership beyond the lab as Chair of the Postdoctoral Association, organizing retreats, workshops, and professional events - Engage in continuous clinical and regulatory education, including ICH/GCP training and clinical trial management, bridging preclinical and clinical research perspectives Translational research • Preclinical models • RNA biology • CRISPR/Cas systems • Drug discovery • Cardiovascular research • biomolecualr research

Metabolic signaling • Insulin & IGF-1 pathways • Noncoding RNA (miRNA, lncRNA) • Liver metabolism • Transgenic mouse models • Systems metabolism • interorgan crosstalks • organokines- Lead and manage multiple research projects in parallel, defining research questions, experimental strategies, and project timelines - Design and generate complex genetic in vivo models, including liver-specific double and triple knockout mouse strains, to investigate hepatic insulin and IGF-1 signaling and interorgan crosstalk in metabolic dysregulation and hepatic carcinogenesis - Initiate and establish a second independent research project focused on noncoding RNA biology, generating preliminary data that directly enabled third-party funding - Develop and characterize total-body microRNA-22 (miR-22) knockout mouse models, assessing metabolic phenotypes and systemic effects - Conduct mechanistic cell culture experiments to validate in vivo findings and dissect molecular pathways underlying metabolic regulation - Integrate in vivo and in vitro approaches to link genetic regulation with metabolic outcomes - Collaborate with radiologists and interdisciplinary scientific experts, combining molecular biology with imaging-based analyses - Contribute to academic self-governance, organizing scientific retreats and workshops as a member of the PhD and Postdoctoral Association - Present research results at national and international conferences, delivering oral and poster presentations Metabolic signaling • Insulin & IGF-1 pathways • Noncoding RNA (miRNA, lncRNA) • Liver metabolism • Transgenic mouse models • Systems metabolism • interorgan crosstalks • organokines