Reinhard Wähler

Dr. rer. nat. Reinhard Wähler

Leiter Forschung und Entwicklung der TISSO Naturprodukte GmbH
Wenden, Deutschland


  • Tisso Naturprodukte GmbH

    10 Jahre 5 Monate

    • Head of Research & Development

      Juli 2013–Heute9 Jahre 8 Monate


      • Development and optimization of nutritional supplements
      • Seminars/presentations: silent inflammation, mitochondrial medicine, microbiome, nutritional strategies for health

    • Research and Development

      Okt. 2012–Heute10 Jahre 5 Monate

      Wenden, Nordrhein-Wesfalen, Germany

  • Grant Writing


    Feb. 2012–Mai 20124 Monate

    Berlin Area, Germany

    Gene Therapy / in vivo Stem Cell Therapy for Type 1 Diabetes

  • Research Scientist, In vivo RNAi Unit

    Cenix Bioscience

    Nov. 2008–Juli 20112 Jahre 9 Monate

    • Development and patenting of an siRNA delivery technology
    • Coordination with external companies and consultant
    • Design of chemically modified siRNA to minimize immune response
    • Heading the internal testing
    • in vivo testing of a commercial siRNA delivery technology

  • Postdoctoral Fellow

    University of Alabama at Birmingham

    Jan. 2005–Sept. 20083 Jahre 9 Monate

    • Development of a melanoma vaccine that targets dendritic cells in vivo
    • Tested promoter activity in vivo using adenoviral vectors
    • Tested the tolerable limit for replication competent adenovirus in viral preparations
    • Published review on targeted viral vectors in Nature Reviews Genetics
    • Wrote grant applications and animal protocols

  • PhD student / Postdoc

    Universitätsklinikum Hamburg Eppendorf

    2000–20044 Jahre

    • Designed, constructed and tested adenoviral vectors in vitro and in vivo
    • Developed a complex tricistronic expression cassette for cancer immunotherapy
    • Led team (surgeon, radiologist, technical staff) in preclinical testing of adenoviral vectors
    • Results led to patent and the founding of Provecs Medical

    Cancer gene therapy: Using adenoviral vectors I developed an immunostimulatory approach to enable the immune system to eliminate the tumor.
    Two tumor nodules…

  • PhD student

    Max Delbrueck Center

    Dez. 1998–Jan. 20001 Jahr 2 Monate

    Please see description under PhD student / Scientist (UKE) above.
    Initial work at the Max Delbrueck Center also included the development of a production system for gutless adenoviral vectors (a.k.a. minimal or helper-dependent adenoviral vectors). Eventually this part of my PhD work was discontinued.

  • Research Associate

    Eberhard Karls Universität Tübingen

    1997–Okt. 19981 Jahr

    Tübingen Area, Germany

    • Ribozyme technology
    • Transcription factors

  • Internship


    März 1995–Apr. 19952 Monate

    Wuppertal, Germany

    Bayer AG, Wuppertal, Germany
    • Cloned fibrosis related marker from mRNA library, expressed and column-purified it

    The internship was followed up by a second stay in the same laboratory as a working student in 1995.

  • Internship

    The Wistar Institute

    Sept. 1994–Dez. 19944 Monate

    Greater Philadelphia Area

    • Studied and tested ribozyme technology, learned basic molecular biology

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